Figure 3.

SOCE inhibition attenuates mast cell Ca²⁺ mobilization and degranulation to different MRGPRX2 agonists. LAD2 cells were treated with indicated concentrations of SKF, and Ca²⁺ mobilization (A–D) and degranulation (E–H) assays were performed following incubation with substance P (A, E), compound 48/80 (B, F), LL-37 (C, G) and (R)-ZINC-3573 (D, H). Data shown are mean ± S.E. of three independent experiments. Statistical significance was determined by two-way ANOVA. *p < 0.05 and **p < 0.01.