Figure 5.

MRGPRX2-induced degranulation of human skin-derived mast cells is attenuated by SOCE inhibition. Human skin-derived mast cells were pre-treated with SKF (50 μM) and exposed to different concentrations of CST-14 (A) or LL-37 (B). Bar graphs show degranulation of mast cells as estimated by β-hexosaminidase release in the supernatant. Data shown are mean ± S.E. of three independent experiments with different human donors. Statistical significance was determined by Student's t-test. *p < 0.05 and **p < 0.01.