Figure 7.

SOCE Inhibition reduces paw edema to compound 48/80. PBS (vehicle) or SKF-treated C57BL/6 mice were exposed to compound 48/80, (C 48/80, left paw) or PBS (right paw) and Evans blue dye was injected i.v. Mice were culled 30 min later. (A) Representative pictures of three mice for each group with dye leakage in the paws are shown. (B) The paws were excised and weighed; the dye was extracted and absorbance of the supernatant was measured at 650 nm. (C,D) Bar graphs shows the paw thickness (C) and histamine levels in serum (D) of mice. Data shown are mean ± S.E. from three experiments (n = 6–13 mice/group). Statistical significance was determined by Student's t-test. *p < 0.05.