Table 1.

Pirfenidone treatment of A549 cells leads to enriched signaling pathways involved in cell cycle, mitosis, and DNA replication.

Pathway name	Source	Pathway ID	Adj. p-value	Coverage [%]
Cell cycle	REAC	REAC:R-HSA-1640170	1.96E-13	17.56
Cell cycle, Mitotic	REAC	REAC:R-HSA-69278	2.28E-12	18.22
Retinoblastoma gene in cancer	WP	WP:WP2446	6.63E-09	33.33
Mitotic prometaphase	REAC	REAC:R-HSA-68877	7.86E-08	22.56
Resolution of sister chromatid cohesion	REAC	REAC:R-HSA-2500257	2.4956E-06	25.20
M phase	REAC	REAC:R-HSA-68886	4.9795E-06	16.62
Cell cycle checkpoints	REAC	REAC:R-HSA-69620	2.3064E-05	17.65
Cell cycle	KEGG	KEGG:04110	2.6264E-05	22.58
Spliceosome	KEGG	KEGG:03040	4.1917E-05	21.64
Mitotic anaphase	REAC	REAC:R-HSA-68882	9.0806E-05	19.49
Mitotic metaphase and anaphase	REAC	REAC:R-HSA-2555396	0.0001	19.39
Separation of sister chromatids	REAC	REAC:R-HSA-2467813	0.0003	19.25
Amplification of signal from the kinetochores	REAC	REAC:R-HSA-141424	0.0003	25.00
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	REAC	REAC:R-HSA-141444	0.0003	25.00
Cell cycle	WP	WP:WP179	0.0003	22.50
RHO GTPases activate formins	REAC	REAC:R-HSA-5663220	0.0004	21.32
G1 to S cell cycle control	WP	WP:WP45	0.0006	28.13
Mitotic spindle checkpoint	REAC	REAC:R-HSA-69618	0.0015	22.22
TP53 regulates transcription of cell cycle genes	REAC	REAC:R-HSA-6791312	0.0017	30.61
G1/S transition	REAC	REAC:R-HSA-69206	0.0018	20.61
Mitotic G1-G1/S phases	REAC	REAC:R-HSA-453279	0.0023	19.59
Processing of capped intron-containing pre-mRNA	REAC	REAC:R-HSA-72203	0.0023	16.81
Telomere C-strand (lagging strand) synthesis	REAC	REAC:R-HSA-174417	0.0033	41.67
S phase	REAC	REAC:R-HSA-69242	0.0045	18.63
DNA replication	KEGG	KEGG:03030	0.0072	30.56