Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 21;10:1322. doi: 10.3389/fgene.2019.01322

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Chauhan, McClure, Hekman, Marsh, Bailey, Daniels, Genereux and Karlsson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Overall beta diversity of the microbiome does not differ by B. burgdorferi infection status; however, specific taxa are significantly over and underrepresented in infected ticks. (A) Beta diversity, measured by weighted Unifrac distance, differed significantly between infected (blue) and uninfected (red) ticks (pseudo-F test = 8.28366, p = 0.001), but (B) this difference disappears once B. burgdorferi is removed from the analysis (pseudo-F test = 1.53959, p = 0.206). (C) LEfSe discriminant analysis shows that reads from B. burgdorferi and Cutibacterium are significantly more abundant (orange) in B. burgdorferi-positive ticks, while reads from three taxa are significantly less abundant (purple), including Rickettsia. (D) The underabundance of Rickettsia persists in LEfSe analysis of female ticks only, and the number of significantly more (orange; 5 taxa) and less (purple; 6 taxa) abundant taxa increases.