Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 21;10:1618. doi: 10.3389/fphys.2019.01618

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Negri, Faris, Berra-Romani, Guerra and Moccia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

TRPC channels in angiogenesis. Representation of the main TRPC channels involved in angiogenesis. TRPC1 mediates angiogenesis after VEGF- (still debated), IGF-, bFGF- and thrombin-induced stimulation. TRPC4 is sensitive to EGF, oxLDL and hypoxia. TRPC3 responds to erythropoietin (EPO) and VEGF stimulation, such as TRPC6, which can be also activated by oxLDL, thrombin and 14,15-EETs. Finally, TRPC5 is sensitive to hypoxia, riluzole and oxLDL-dependent activation.