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. 2020 Jan 21;10:1618. doi: 10.3389/fphys.2019.01618

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Copyright © 2020 Negri, Faris, Berra-Romani, Guerra and Moccia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV channels in angiogenesis. TRPV1, TRPV2, and TRPV4 are the main TRPV isoforms that mediate angiogenesis. TRPV1 is involved in angiogenesis in response to: VEGF, capsaicin, evodiamine, simvastatin, EPO, epigallocatechin-3-gallate, and 14,15-EETs. Shear stress-, cyclic strain-, 4α- PDD-, ROS-, AA- and GSK-mediated TRPV4 activation participate to angiogenesis. Finally, TRPV2 stimulation with lysophosphatidylcoline can play a role in this process.