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. 2020 Jan 21;10:1618. doi: 10.3389/fphys.2019.01618

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Copyright © 2020 Negri, Faris, Berra-Romani, Guerra and Moccia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPM and TRPA1 channels in angiogenesis. Some TRPM isoforms are shown to be involved in angiogenesis. In particular, TRPM2 stimulates angiogenesis after VEGF stimulation, whereas TRPM4 is activated by H2O2, stroke and oxygen-glucose deprivation. TRPM7 regulates endothelial cell proliferation and tube formation being sensitive to a reduction in intracellular Mg2⁺ concentration and to oxygen-glucose deprivation. Finally, TRPA1 promotes angiogenesis in response to AITC and upon simvastatin-dependent TRPV1 activation.