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. 2020 Jan 21;10:1360. doi: 10.3389/fgene.2019.01360

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Copyright © 2020 Li, Liu, Huang, Cai, Song, Xie, Liu, Chen, Xu, Zeng, Chu and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of RPS6KB1 and CREB1 is upregulated and positively correlates with CXCL8 expression, while Bcl2 associated agonist of cell death (BAD) is downregulated and negatively correlates with CXCL8 expression in colorectal cancer (CRC). (A) Protein-protein interaction (PPI) network. (B) Expression of RPS6KB1 mRNA expression in normal (N = 81), CRC-early stage (N = 44), and CRC-advanced stage (N = 37) groups. (C) Expression of CREB1 mRNA expression in normal (N = 81), CRC-early stage (N = 44) and CRC-advanced stage (N = 37) groups. (D) Expression of BAD mRNA expression in Normal (N = 81), CRC-early stage (N = 44), and CRC-advanced stage (N = 37) groups. (E) Expression of RPS6KB1, CREB1, BAD mRNAs compared with that of CXCL8 mRNA in CRC (N = 81). Statistical signiﬁcance was performed by the Mann-Whitney U test. **p < 0.01, ***p < 0.001.