FIGURE 13.

Neutrophil infiltration in the lung and neutrophil migration to the peritoneal cavity in CLP mice. Evaluation of (A) neutrophil infiltration in the lungs and (B) migration of neutrophils to the peritoneal cavity in control mice (Sham) and mice submitted to CLP-induced sepsis; CLP mice treated with sodium ertapenem (30 mg/kg s.c., CLP + ATB), or CLP + ATB + GlcN (300 mg/Kg, i.v., CLP + ATB + GlcN). Lung neutrophil sequestration was estimated by the myeloperoxidase assay (MPO) in the organ homogenate 6 h after CLP-induced sepsis. Neutrophil count into the peritoneal cavity was performed using the Coulter^® apparatus. The results are expressed as mean ± SEM and are representative of 4–5 experiments. ^∗p < 0.05 vs. sham; ^#p < 0.05 vs. CLP + ATB. One-way ANOVA followed by Dunnett’s post-test.