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. 2019 Dec 3;53(1):e12724. doi: 10.1111/cpr.12724

Table 1.

Rbm14 knockout in mice is embryonic lethal

Genotype Number of progenies
Rbm14 +/+ × ♂ Rbm14 +/− Rbm14 +/− × ♂ Rbm14 +/+ Rbm14 +/− × ♂ Rbm14 +/−
Rbm14 +/+ 65 (46.1%) 69 (51.5%) 51 (32.9%)
Rbm14± 76 (53.9%) 65 (48.5%) 104 (67.1%)
Rbm14 −/− 0 0 0
Mendelian ratio 1:1:0 1:1:0 1:2:1

Quantification of pups with different genotypes by three different mating strategies: ♀ Rbm14 +/+ × ♂ Rbm14 +/−; ♀ Rbm14 +/− × ♂ Rbm14 +/+ and ♀ Rbm14 +/− × ♂ Rbm14 +/−. No Rbm14−/− pups were produced by interbreeding of Rbm14 +/− male and female mice, indicating that homozygous deletion of Rbm14 +/− results in embryonic lethality. More than 10 litters of pups were genotyped and quantified in each group (for ♀ Rbm14 +/+ × ♂ Rbm14 +/−, n = 141; for ♀ Rbm14 +/− × ♂ Rbm14 +/+, n = 134 and for ♀ Rbm14 +/− × ♂ Rbm14 +/−, n = 155).