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Schematic representation of OPG‐mediated inhibition of OC differentiation and bone resorption by induction of AMPK signalling‐mediated autophagy. OPG competitively combines with RANKL, causing the inhibition of OC differentiation, which is a key regulator of bone metabolism. Lysosomes, which secrete matrix proteases (such as CTSK) and regulate the function of OC by the control of pH, also play a role in this process
