TABLE 2.
Characteristics of 26 Aspergillus fumigatus isolates from the hospital
| Strain | Source | Mating type | Azole resistance | Cyp51A mutation(s) | MIC (mg/liter) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ITCa | VOR | POS | BRO | EPO | TEB | PRC | DIF | PRO | IMA | |||||
| C475 | Clinical | MAT1-2 | S | None | 0.5 | 1 | 0.25 | 4 | 8 | 4 | 1 | 2 | 8 | 0.5 |
| C477 | Clinical | MAT1-1 | S | None | 0.5 | 1 | 0.25 | 4 | 4 | 4 | 0.5 | 2 | 8 | 0.5 |
| C478 | Clinical | MAT1-1 | S | None | 1 | 0.5 | 0.13 | 2 | 4 | 4 | 1 | 4 | 8 | 0.5 |
| C479 | Clinical | MAT1-1 | S | None | 0.5 | 1 | 0.13 | 2 | 4 | 2 | 0.5 | 2 | 4 | 0.25 |
| C481 | Clinical | MAT1-1 | S | None | 0.5 | 0.5 | 0.06 | 1 | 2 | 1 | 0.25 | 1 | 2 | 0.13 |
| C482 | Clinical | MAT1-1 | S | None | 0.5 | 0.5 | 0.13 | 2 | 2 | 2 | 0.25 | 1 | 4 | 0.5 |
| C483 | Clinical | MAT1-1 | S | None | 0.5 | 0.5 | 0.13 | 1 | 2 | 2 | 0.25 | 2 | 4 | 0.25 |
| C485 | Clinical | MAT1-2 | R | TR34/L98H/S297T/F495I | >16 | 2 | 1 | >32 | >32 | 32 | >32 | >32 | >32 | 16 |
| C487 | Clinical | MAT1-2 | S | None | 0.5 | 1 | 0.13 | 2 | 2 | 2 | 0.5 | 2 | 4 | 0.5 |
| C2089 | Clinical | MAT1-1 | S | None | 1 | 0.5 | 0.25 | 2 | 4 | 4 | 1 | 4 | 4 | 0.25 |
| C2090 | Clinical | MAT1-2 | S | None | 0.5 | 0.25 | 0.5 | 1 | 4 | 2 | 0.5 | 2 | 2 | 0.25 |
| C2091 | Clinical | MAT1-1 | S | None | 0.5 | 0.5 | 0.25 | 2 | 4 | 4 | 1 | 4 | 8 | 0.5 |
| C2092 | Clinical | MAT1-1 | S | None | 0.5 | 0.25 | 0.25 | 2 | 4 | 4 | 0.5 | 2 | 4 | 0.25 |
| C2093 | Clinical | MAT1-2 | S | None | 1 | 0.5 | 0.25 | 4 | 8 | 4 | 0.5 | 4 | 8 | 0.5 |
| C2094 | Clinical | MAT1-2 | S | None | 0.5 | 0.5 | 0.25 | 2 | 2 | 2 | 0.25 | 1 | 2 | 0.13 |
| C2095 | Clinical | MAT1-1 | S | None | 1 | 0.5 | 0.25 | 2 | 4 | 2 | 0.25 | 2 | 4 | 0.25 |
| E2041-2 | Environmental | MAT1-2 | R | None | >16 | 2 | 0.5 | 16 | >32 | >32 | 1 | 32 | >32 | 2 |
| E2042-1 | Environmental | MAT1-2 | R | TR34/L98H | >16 | 4 | 1 | 8 | >32 | 16 | 0.5 | 8 | 32 | 1 |
| E2045-1 | Environmental | MAT1-1 | R | TR34/L98H | >16 | 4 | 0.5 | 16 | >32 | >32 | 2 | 16 | >32 | 4 |
| E2045-2 | Environmental | MAT1-1 | R | TR34/L98H | >16 | 2 | 0.5 | 32 | >32 | >32 | 2 | 16 | >32 | 2 |
| E2048-2 | Environmental | MAT1-1 | R | TR34/L98H | >16 | 4 | 1 | 16 | >32 | 32 | 1 | 16 | >32 | 2 |
| E2034-2 | Environmental | MAT1-2 | S | None | 0.5 | 1 | 0.13 | 2 | 4 | 2 | 0.5 | 2 | 8 | 0.25 |
| E2038-2 | Environmental | MAT1-1 | S | None | 1 | 0.5 | 0.25 | 2 | 8 | 4 | 1 | 4 | 8 | 0.5 |
| E2041-3 | Environmental | MAT1-2 | S | None | 1 | 0.5 | 0.25 | 1 | 4 | 2 | 0.25 | 2 | 4 | 0.25 |
| E2052-3 | Environmental | MAT1-1 | S | None | 1 | 1 | 0.25 | 4 | 8 | 4 | 1 | 4 | 8 | 0.25 |
| E2083-3 | Environmental | MAT1-1 | S | None | 0.5 | 0.5 | 0.25 | 1 | 2 | 2 | 0.5 | 2 | 4 | 0.25 |
a
ITC, itraconazole; VOR, voriconazole; POS, posaconazole; BRO, bromuconazole; EPO, epoxiconazole; TEB, tebuconazole; DIF, difenoconazole; PRO, propiconazole; IMA, imazalil; PRC, prochloraz; R, azole resistance; S, azole susceptibility.