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NHC inhibition of protein expression of COX1 and SDH-Aa
| Expt | IC50 (μM) |
SDH-A/COX1 ratio | |
|---|---|---|---|
| COX1 | SDH-A | ||
| 1 | 5.3 | 10.0 | 1.9 |
| 2 | 6.5 | 24.8 | 3.8 |
| 3 | 7.7 | 15.4 | 2.0 |
| 4 | 5.3 | 16.7 | 3.2 |
NIC inhibition values were calculated by four-parameter curve fit by using GraphPad Prism 8 software. The results from four individual experiments are shown. The averages ± the standard deviations for COX1 and SDH-A (IC50 [μM]) and for the SDH-A/COX1 ratio were 6.2 ± 1.1, 16.7 ± 6.1, and 2.7 ± 0.9, respectively.
