TABLE 3.

Relative mtDNA and extracellular lactate levels in HepG2 cells after a 14-day incubation with various compounds

Treatment compound	Treatment concn	Mean ± SDa
		Relative mtDNA level	Lactate production
Mock-treated control	NAb	100 ± 25.8	100
NHC	10 μM	115.0 ± 92.4	103.7 ± 21.2
	100 μM	68.4 ± 17.6	111.5 ± 38.5
ddC	1 μM	7.1 ± 2.8*	195.9 ± 61.9
EtBr	0.5 μg/ml	19.6 ± 12.1	242.5 ± 47.8**

^aValues are means from three independent experiments (with one biological and three technical repeats each). *, P < 0.05; **, P < 0.01 (compared to a mock-treated control).

^bNA, not applicable.