TABLE 4.

Relative mtDNA and extracellular lactate levels in CEM cells after a 14-day incubation with various compounds

Treatment compound	Treatment concn	Mean ± SDa
		Relative mtDNA level	Lactate production
Mock-treated control	NAb	100 ± 10.8	100 ± 0
NHC	10 μM	80.0 ± 19.1*	118.1 ± 3.4**
	30 μM	78.7 ± 15.8*	101.8 ± 12.7
ddC	0.2 μM	0.15 ± 0.06***	310.5 ± 71.2**
EtBr	0.1 μg/ml	0.39 ± 0.11***	260.7 ± 39.3**

^aValues are means from three independent experiments (with one biological and three technical repeats each). *, P < 0.05; **, P < 0.01; ***, P < 0.001 (compared to a mock-treated control).

^bNA, not applicable.