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L-269289 resensitizes echinocandin-resistant strains to caspofungin. (A) Deletion of CDC43 increased the susceptibility of echinocandin-resistant C. albicans to caspofungin. Assays were performed as described for Fig. 1B. (B) L-269289 renders echinocandin-resistant C. albicans responsive to treatment. Assays were performed on indicated echinocandin-resistant strains as described for Fig. 3B.
