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Relationship between the development of fluoroquinolone resistance and QRDR mutations. The clinical isolates were grown on sBHI agar containing moxifloxacin (from 0.03 to 128 mg/liter) at 37°C under an atmosphere of 5% CO2 for 48 h. y axis, number of clinical isolates and obtained mutants with reduced fluoroquinolone susceptibility or fluoroquinolone resistance. Defined and undefined/non-QRDR mutations were both considered. Moxifloxacin MIC of >1 mg/liter indicates resistance.
