TABLE 4.
Fluoroquinolones and β-lactam MIC values of gyrA and/or ompP2 mutants derived from strain Rd
Strain | MICa
(mg/liter) |
||||||
---|---|---|---|---|---|---|---|
MXF | LVX | TFX | SFX | AMP | CRO | CTX | |
Rd | 0.015 | 0.015 | 0.008 | 0.002 | 0.25 | 0.004 | 0.015 |
Rd_GyrASer84Leu | 0.13 | 0.13 | 0.06 | 0.015 | 0.25 | 0.004 | 0.015 |
Rd_GyrAAsp88Asn | 0.06 | 0.06 | 0.03 | 0.015 | 0.25 | 0.004 | 0.015 |
Rd_GyrAAsp88Tyr | 0.06 | 0.06 | 0.03 | 0.008 | 0.25 | 0.004 | 0.015 |
Rd_GyrAGlu153Lys | 0.06 | 0.06 | 0.015 | 0.015 | 0.25 | 0.004 | 0.015 |
Rd_GyrAΔGlu606 | 0.03 | 0.03 | 0.015 | 0.008 | 0.25 | 0.004 | 0.015 |
Rd_GyrBser467Tyr | 0.06 | 0.06 | 0.015 | 0.008 | 0.25 | 0.004 | 0.015 |
Rd_GyrBGlu469Asp | 0.06 | 0.06 | 0.008 | 0.004 | 0.25 | 0.004 | 0.015 |
Rd_ΔompP2 | 0.06 | 0.06 | 0.015 | 0.008 | 0.25 | 0.06 | 0.03 |
Rd_ΔompP2/pMC-tandem GFP(−) | 0.03 | 0.06 | 0.015 | 0.008 | 0.25 | 0.06 | 0.03 |
Rd_ΔompP2/pMCompP2 | 0.015 | 0.015 | 0.008 | 0.002 | 0.25 | 0.004 | 0.015 |
Rd_GyrASer84Leu + ΔompP2 | 0.25 | 0.5 | 0.06 | 0.06 | 0.25 | 0.06 | 0.03 |
MXF, moxifloxacin; LVX, levofloxacin; TFX, tosufloxacin; SFX, sitafloxacin; AMP, ampicillin; CRO, ceftriaxone; CTX, cefotaxime.