TABLE 3.

Kinetic parameters of vaborbactam inactivation of various β-lactamases

Enzyme	Mean ± SD			Kd (nM)
	k2/K (M−1 s−1)	koff (s−1)	Residence time (min)
KPC-2	(5.5 ± 0.5) × 103	0.000043 ± 0.000006	394 ± 50	7.8
KPC-3	(6.7 ± 0.3) × 103	0.000030 ± 0.000001	559 ± 28	4.4
BKC-1	(1.2 ± 0.1) × 104	0.00040 ± 0.00008	43 ± 8	33
FRI-1	(3.4 ± 0.1) × 103	0.0017 ± 0.0001	9.8 ± 0.7	509
SME-2	(5.0 ± 0.2) × 103	0.00024 ± 0.00002	71 ± 7	47
CTX-M-15	(2.3 ± 0.2) × 104	0.0009 ± 0.0002	19 ± 1	40
AmpC	(2.4 ± 0.2) × 104	0.0052 ± 0.0003	3.2 ± 0.2	220