TABLE 1.

Activity of meropenem-vaborbactam against Enterobacterales isolates collected in 31 U.S. hospitals during 2016 to 2018^c

Organism (no. of isolates)	MIC (mg/liter)			% of isolates susceptible to meropenem-vaborbactam applying interpretative criteria of:
	50%	90%	Range	CLSIa	EUCASTb
CRE (152)	0.06	2	≤0.015 to >32	95.4	98.0
KPC producers (124)	0.03	0.5	≤0.015 to 8	99.2	100.0
KPC-2 producers (51)	0.03	1	≤0.015 to 2	100.0	100.0
KPC-3 producers (72)	0.03	0.5	≤0.015 to 8	98.6	100.0
MBL and OXA-48-like producers (7)	8		4 to >32	14.3	57.1
CPE (134)	0.03	1	≤0.015 to >32	94.8	97.8
Carbapenemase negative (18)	1	4	0.25 to 4	100.0	100.0

^aCLSI criteria are provided in reference 26.

^bEUCAST criteria are provided in reference 27.

^cCRE, carbapenem-resistant Enterobacterales; MBL, metallo-β-lactamase; CPE, carbapenemase-producing Enterobacterales.