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Simulations for protection by the IPERGAY strategy in female genital tract tissue (a) and rectal tract tissue (b). The blue arrows indicate time of dose of preexposure prophylaxis regimen (either maraviroc monotherapy or maraviroc in combination with tenofovir or emtricitabine), and the pink-shaded region represents exposure incident to HIV. The dashed red line represents the 90% efficacy threshold for protection against HIV infection.
