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. 2020 Jan 21;10:1578. doi: 10.3389/fphar.2019.01578

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Copyright © 2020 Zhang, Zhang, Gao, Cui, Yang, van Duijn, Wang, Hu, Wang and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Changes of body parameters and cytokines in BDS mice compared to the control group. (B) Changes of body parameters and cytokines in SPN administration groups mice compared to the model group. IL-2, interleukin-2; JAK1, janus kinase-1; SHP2, tyrosine-protein phosphatase non-receptor type 11; GRB, growth factor receptor-bound protein; SOS, guanine nucleotide exchange factor; STAT, signal transducer and activator of transcription; Bcl-2, B-cell lymphoma-2; Bcl-XL, Bcl-2 like 1; c-Myc, v-myc avian myelocytomatosis viral oncogene homolog; p21, cki.