Table 4.
Renal expression of P2 receptors
| Vasculature/Glomeruli | Mesangial Cells | Podocytes | Proximal Tubules | Loop of Henle | Distal Convoluted Tubule | Collecting Duct | |
|---|---|---|---|---|---|---|---|
| P2Y1 | IM: glomeruli (24, 153); mRNA: (24) | IM (24, 520); WB: mouse culture (437); mRNA: human culture (536) | IM (24, 214); mRNA (214); mouse (150); mouse immortalized (147) | IM: PST-A (520); mRNA: PCT (21) | mRNA: tDL, tAL, mTAL (21) | mRNA: mouse immortalized DCT (159) | mRNA: OMCD (21); mouse IMCD cell line (330) |
| P2Y2 | IM, mRNA: glomeruli (24) | IM (24); cultured cells (440); WB: mouse culture (437); mRNA (191); cultured cells (440); human culture (536); mouse culture (437) | IM (24); mRNA: mouse immortalized (147) | mRNA: PCT (21, 267); PST (267) | IM: tAL, mTAL (intra), cTAL (intra) (520); mRNA: tDL, tAL (21, 267), mTAL (21, 267), cTAL (267); mouse mTAL (327) | mRNA: mouse immortalized DCT (116, 159) | IM: CCD (PC and IC, PC: intra) (553); OMCD (PC and IC, PC: intra-A/B) (553); MCD IC (520), IMCD (A > B) (267); IMCD (PC and IC, PC: B > A) (553); WB: IMCD (267); mRNA: CD (553); CCD (267), OMCD (21, 267), IMCD (267), mouse ISOM (327) |
| P2Y4 | mRNA: glomeruli (24); mRNA: vasa recta (110) | WB: mouse culture (437); mRNA (191); human culture (536); mouse culture (437) | IM: PCT (B) (520); mRNA: PCT (21) | mRNA: tAL, mTAL (21) | IM: CCD, OMCD, IMCD (PC and IC, PC: all A) (554); mRNA: OMCD (21); CD (NaCl restriction) (554) | ||
| P2Y6 | mRNA: glomeruli (24); mRNA: vasa recta (110) | IM: cultured cells (440); mRNA: cultured cells (440); human culture (536) | mRNA: mouse immortalized (147) | mRNA: PCT, PST (22) | mRNA: tDL (22), mTAL (22), cTAL (22); mouse mTAL (327) | mRNA: mouse immortalized DCT (159) | IM: CCD, OMCD, IMCD (PC and IC, PC: all intra-A) (554); mRNA: CD (554); CCD, OMCD (22); mouse ISOM (327) |
| P2Y11 | mRNA: human culture (536) | ||||||
| P2Y12 | mRNA: human culture (536) | mRNA: mouse ISOM (327) | |||||
| P2Y13 | mRNA: mouse ISOM (327) | ||||||
| P2Y14 | mRNA: mouse ISOM (327) | ||||||
| P2X1 | IM, autoradiography: VSMC arcuate and interlobular arteries (86, 336); VSMC afferent arterioles (86, 336, 589); IM: renal arteries (305); IM: glomeruli (153); mRNA: vasa recta (110) | mRNA: human culture (536); mouse culture (437) | mRNA: mouse (150) | mRNA: mouse mTAL (327) | mRNA: mouse immortalized DCT (116) | NaCl restriction: IM: CCD, OMCD, IMCD (all IC); mRNA: CD (554); mouse ISOM (327) | |
| P2X2 | WB: mouse culture (437); mRNA: human culture (536); mouse culture (437) | mRNA: mouse (150) | mRNA: mouse immortalized DCT (116) | mRNA: mouse ISOM (327) | |||
| P2X3 | mRNA: vasa recta (110) | mRNA: mouse culture (437) | mRNA: mouse (150) | mRNA: mouse immortalized DCT (116) | mRNA: mouse IMCD cell line (330); mouse ISOM (327) | ||
| P2X4 | IM: EC renal artery (305, 336) | WB: mouse culture (437); mRNA: human culture (536); mouse culture (437) | mRNA: mouse (150) | IM: low level (520) | IM: tDL (520); mRNA: mouse mTAL (327) | IM: B (520); mRNA (520); mouse (119); mouse immortalized DCT (116, 159) | IM: low level (520); CCD, OMCD, IMCD (all PC and IC, PC: A/B) (554); mRNA: CD (554) |
| P2X5 | mRNA: human culture (536) | mRNA: mouse (150) | IM: PST-A (520) | mRNA: mouse mTAL (327) | mRNA: mouse immortalized DCT (116, 159) | IM: CCD << OMCD < IMCD principal cells (520); | |
| P2X6 | mRNA: human culture (536) | mRNA: mouse (150) | IM: low level (520) | IM: B (520); mRNA (520); mouse (119); | IM: low level (520); CCD, OMCD, IMCD (all PC and IC, PC: A/B) (554); mRNA: CD (NaCl restriction) (554) | ||
| P2X7 | IM: EC renal artery (305, 336); IM, mRNA: glomeruli (538); mRNA: vasa recta (110); IM: EC vasa recta (335) | IM (191); mRNA (191); human culture (536); mouse culture (437) | mRNA: mouse (150); mouse immortalized (147) | IM: mouse (198); mouse ISOM (327) | |||
Data are from rat kidney unless otherwise stated. Reference numbers are in parentheses. (A), apical; (B), basolateral; CCD, cortical collecting duct; CD, collecting duct; cTAL, cortical thick ascending limb; EC, endothelial cells; IC, intercalated cells; IM, immunostaining; IMCD, inner medullary CD; (intra), intracellular; ISOM, inner stripe of outer medulla; OMCD, outer medullary CD; PC, principal cell; PCT, proximal convoluted tubule; PST, proximal straight tubule; tAL, thin ascending limb; mTAL, medullary thick ascending limb; tDL, thin descending limb; WB, Western blotting. [Updated and modified from Vallon (523).]