Fig. 2.
Mitochondrial complex I respiration supported by ADP (5 mM) and malate (2 mM) in the presence of either submaximal pyruvate (A; 25 µM), maximal pyruvate (B; varied 6 to 38 mM), submaximal glutamate (C; 50 µM) or maximal glutamate (D; varied 4 to 20 mM) in control (CON) and type 1 diabetes (T1D) women and men. Right panel of (A) through (D) is the absolute change from each T1D participant relative to the average of their sex-matched control (△T1D-CONavg). Boxes represent the interquartile range, whiskers show the maximum and minimum, the horizontal line indicates the median and the cross indicates the mean. *P < 0.05 versus women, **P < 0.01 versus women. f, female; m, male; mJO2, mitochondrial oxygen flux; Wt, weight. n = 6–8 for CON women; n = 6–7 for CON men; n = 8–9 for T1D women; n = 6 for T1D men.