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. 2019 Dec 9;318(1):F273–F282. doi: 10.1152/ajprenal.00388.2019

Fig. 5.

Fig. 5.

TNF-α inhibits Na+-K+-2Cl− cotransporter (NKCC2) isoform B (NKCC2B) and phosphorylated (p-)NKCC2 expression in a mouse macula densa-like cell line (MMDD1 cells). NKCC2B mRNA (A) and p-NKCC2 (B) expression were determined in cultured MMDD1 cells treated for 4 h with normal-salt medium (NSM) containing either TNF-α (1 nM) or vehicle; n = 6. NKCC2B mRNA (C) and pNKCC2 (D) expression were determined in cultured MMDD1 cells treated for 4 h with low-salt medium (LSM) medium containing either TNF-α (1 nM) or vehicle; n = 6.