Fig. 6.

Effects of silencing TNF-α and Na⁺-K⁺-2Cl⁻ cotransporter isoform B on water intake, body weight, and blood pressure. Mice injected with U6, U6-TNF-ex4, or a combination of U6-TNF-ex4 and U6-N2B-ex4 were acclimatized for 3 days in metabolic cages and given tap water ad libitum. Water intake (A) and body weight (B.W.; B) were determined in mice that ingested a low-salt diet (LSD) for 7 days. Mean arterial pressure (MAP) values (C) obtained by radiotelemetry are shown for day 7; n = 12. ns, Not significant.