Fig. 1.

Impact of phosphate restriction on kidney and body weight in pcy/pcy mice. A: mice that consumed the phosphate-restricted (Phos-rest) diet demonstrated reduced body weight compared with age- and sex-matched mice fed the control diet (n ≥ 4 per group; at study end, P < 0.001 for male mice versus control and P < 0.001 for female mice versus control by 2-way ANOVA; data are plotted without error bars to preserve figure clarity). B: mice that consumed the phosphate-restricted diet demonstrated a reduced kidney weight-to-body weight ratio (KW/BW) compared with age- and sex-matched mice fed the control diet (**P < 0.01 by Student’s t-test; n ≥ 4 per group).