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Chronic phosphate restriction alters mineral metabolism parameters in pcy/pcy mice. Serum phosphate was reduced (A) while serum calcium was increased (B) in the phosphate-restricted (Phos-rest) group. Both FGF23 and parathyroid hormone (PTH) were markedly lower (C and D) while kidney Klotho gene expression (E) was significantly higher in mice fed a phosphate-restricted diet. (**P < 0.01, ***P < 0.001 by Student’s t test; n ≥ 8 per group).
