Fig. 2.

Line graphs showing comparison of end expiration (EE) (A), tidal inspiration (TI) (C), forced inspiration (FI) (B) and transdiaphragmatic pressure (pdi) (D) before and after the Botox injection at 2–4 wk and at 6–12 mo. Note reduction in the esophagogastric junction (EGJ) pressures at end expiration (P < 0.01), tidal inspiration (P < 0.01), and deep breath at 2–4 wk (P < 0.01) and return of pressures at 6–12 mo after the Botox injection. The pdi pressures were not affected by the Botox injection (P = 0.66) except in one patient who had complete paralysis of hiatal contraction by Botox at 2 wk.