Table 2.
Embryological origin of commissural interneurons
Cell Type | Location | Projection | Transmitter | Transcription Factor | Contralateral Terminations | Action | References |
---|---|---|---|---|---|---|---|
dI5 | VI | contralateral | Glutamate | Lmx1b | dorsal horn | ? | Lu et al. (2015); Vallstedt and Kullander (2013) |
dI6 | VII–VIII | contralateral | GABA/glycine | Dmrt3 | VII–IX, MN | Control of gait | Andersson et al. (2012); Dyck et al. (2012) |
V0D | VII–VIII | contralateral | GABA/glycine | Dbx1 | VII–IX, MN | Coordination of left–right alternation at low speed | Talpalar et al. (2013) |
V0V | VII–VIII | contralateral | Glutamate | Dbx1 | VII–VIII | Coordination of left–right alternation at high speed | Talpalar et al. (2013) |
V0C | VII, X | contralateral/bilateral | Acetylcholine | Dbx1 | IX, VII, MN | Modulation of motoneuron firing frequency | Stepien et al. (2010); Zagoraiou et al. (2009) |
V3 | VII | contralateral/bilateral | Glutamate | Nkx2.2 | VII–IX, MN | Control of rhythmicity | Briscoe et al. 1999); Zhang et al. (2008) |
Roman numerals refer to laminae of Rexed. MN, contacts on contralateral motoneurons; ?, unknown action.