Fig. 8.

Amphiregulin (AREG) supplementation promotes recovery following inflammatory assault. Mice given intranasal recombinant AREG during 3 days of recovery following 8 days of dust extract (DE) exposure exhibited fewer inflammatory cell infiltrates than control mice (A), and inflammatory cell subsets in dissociated whole lung were influenced by AREG treatment (total leukocytes, neutrophils, and activated macrophages significantly suppressed, but T cells elevated) (B). Proinflammatory modulators in bronchoalveolar lavage fluid (BALF) were uniformly attenuated in AREG-treated groups, whereas prorepair proteins IL-10 and AREG were augmented, compared with vehicle (C). Administration of AREG during recovery also stimulated significantly higher levels of IL-10 and AREG in serum (D). *P < 0.05, #P < 0.01. NSD, no significant difference.