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. 2020 Jan 28;75(3):304–316. doi: 10.1016/j.jacc.2019.11.032

Table 3.

Multivariable Cox Regression Analysis of Association Between ECV% and All-Cause Mortality

ECV%
95% CI for HR
p Value HR Lower Upper
All-cause mortality
 Univariable
 Model 1
 ECV% <0.001 1.145 1.068 1.228
 ECV% 0.003 1.124 1.047 1.207
 Age, yrs <0.001 1.086 1.049 1.125
 Male 0.001 2.921 1.520 5.614
 Model 2
 ECV% 0.013 1.100 1.020 1.186
 Age, yrs <0.001 1.093 1.054 1.133
 Male 0.004 2.649 1.363 5.148
 LVEF <50% 0.213 1.535 0.782 3.012
 Late gadolinium enhancement 0.329 1.351 0.738 2.475
 Model 3
 ECV% 0.033 1.088 1.007 1.176
 Age, yrs <0.001 1.094 1.054 1.135
 Male 0.005 2.591 1.325 5.067
 LVEF <50% 0.233 1.527 0.761 3.064
 Late gadolinium enhancement 0.508 1.233 0.663 2.293
 Peak aortic-jet velocity, m/s 0.213 0.788 0.541 1.147
 Model 4
 ECV% 0.027 1.087 1.009 1.171
 STS-PROM score, % <0.001 1.280 1.125 1.457
 Model 5
 ECV% 0.042 1.091 1.003 1.187
 Known coronary disease 0.028 1.965 1.077 3.585
 NYHA functional class III/IV 0.024 2.102 1.103 4.007
 Atrial fibrillation 0.013 2.602 1.223 5.538
 LV mass index 0.313 0.994 0.983 1.006
 LA volume index 0.204 1.007 0.996 1.018
Cardiovascular mortality
 Univariable
 ECV% 0.003 1.215 1.068 1.382

Late gadolinium enhancement incorporates both infarct and noninfarct patterns. p Values in bold are statistically significant.

HR = hazard ratio; LA = left atrial; LVEF = left ventricular ejection fraction; other abbreviations as in Tables 1 and 2.