Table 3A.
Pharmacokinetic parameters for all studied antimicrobials
| Parameters (mean) | n | Dose (mg) | τ (h) | Cmax (µg/mL) | Cmin (µg/mL) | Css (µg/mL) | AUC0-τ (µg.h/mL) | Vd (L) | T1/2 elimination (h) |
|---|---|---|---|---|---|---|---|---|---|
| Ertapenem HD | 5 | 1000 | 24 | 17.28 | 5.75 | - | 181.90 | 35 | 4.41 |
| Ertapenem BD | 2 | 1000 | 24 | 32.39 | 17.86 | - | 327.23 | 30 | 6.79 |
| Imipenem HD Intermittent infusion | 4 | 500 | 6 | 13.00 | 2.10 | - | 144.88 | 25.60 | 1.29 |
| Imipenem BD Intermittent infusion | 4 | 500 | 6 | 15.30 | 3.35 | - | 209.88 | 20.70 | 1.51 |
| Imipenem HD Continuous infusion | 2 | 2000 | 24 | 1.43 (D*) | 0.78 (D*) | 2.74 | - | - | - |
| Imipenem BD Continuous infusion | 5 | 2000 | 24 | 4.96 (D*) | 2.33 (D*) | 7.19 | - | - | - |
| Doripenem HD | 3 | 500 | 8 | 10.16 | 4.29 | - | 65.56 | 33.67 | 2.59 |
| Doripenem BD | 7 | 500 | 8 | 12.82 | 5.62 | - | 80.98 | 52.61 | 4.21 |
| Ceftriaxone HD | 2 | 2000 | 24 | 225.62 | 5.16 | - | 235.32 | 51.32 | 4.19 |
| Ceftriaxone BD | 4 | 2000 | 24 | 283.65 | 6.85 | - | 415.37 | 40.13 | 5.76 |
| Piperacillin HD Intermittent infusion | 5 | 4000 | 6 | 145.62 | 35.56 | - | 122.52 | 38.29 | 3.61 |
| Piperacillin BD Intermittent infusion | 2 | 4000 | 6 | 78.35 | 39.82 | - | 147.63 | 50.99 | 3.99 |
| Piperacillin HD Continuous infusion | 10 | 16000 | 24 | 91.62 (D*) | 66.38 (D*) | 158.71 | 90.47 | - | - |
| Piperacillin BD Continuous infusion | 9 | 16000 | 24 | 147.04 (D*) | 109.76 (D*) | 256.54 | 42.74 | - | - |
| Ofloxacin HD | 14 | 200 | 12 | 8.47 | 3.38 | - | 64.73 | 32.54 | 6.58 |
| Ofloxacin BD | 8 | 200 | 12 | 8.77 | 2.44 | - | 52.02 | 51.46 | 8.72 |
| Linezolid HD | 2 | 600 | 12 | 17.55 | 6.68 | - | 129.63 | 46.76 | 6.33 |
| Linezolid BD | 3 | 600 | 12 | 21.50 | 4.30 | - | 131.31 | 30.70 | 4.59 |
| Daptomycin HD | 4 | 6 mg/kg | 24 | 55.22 | 7.53 | - | 477.72 | 20.26 | 8.53 |
| Daptomycin BD | 7 | 6 mg/kg | 24 | 54.93 | 10.91 | - | 510.99 | 17.70 | 11.94 |
| Metronidazole HD | 12 | 500 | 8 | 15.97 | 10.61 | - | 262.57 | 42 | 8.22 |
| Metronidazole BD | 12 | 500 | 8 | 18.63 | 10.72 | - | 236.17 | 54 | 10.18 |
| Fluconazole HD | 2 | 400 | 12 | 17.40 | 9.10 | - | 114.39 | 73.38 | 28.54 |
| Fluconazole BD | 1 | 400 | 12 | 14.60 | 7.60 | - | 96.44 | 103.71 | 33.85 |
| Voriconazole BD | 3 | 3 mg/kg | 12 | 7.37 | 4.79 | - | 55.00 | 65.55 | 7.19 |
Vd = CLs/Kel; Kel = Ln2/T1/2Kel; T1/2Kel = elimination half-life; D* = loading dose; Vd = volume of distribution; T1/2 = elimination half-life; τ = time interval between two administrations; Cmax = maximum arterial concentration at the end of infusion; Cmin = trough arterial concentration; Css = the steady-state arterial concentration for continuous infusion; AUC0-τ = area under the curve for plasma concentrations between 0 and τ; n = number of patients.