Table 4.
PK/PD parameters for all studied antibiotics
| Antibiotic | Isolated Pathogen | MIC (µg/mL) | T% > MIC | IQ = Cmax/CMI or Css/CMI |
|---|---|---|---|---|
| Imipenem | Pseudomonas aeruginosa (1) | 3 | 34 | 4 |
| Escherichia coli (1) | 1 | 57 | 11 | |
| Enterococcus faecalis (1) | 3 | 37 | 4 | |
| Streptococcus sp. (1) | 2 | 57 | 9 | |
| Klebsiella pneumoniae (1) | 0.5 | 85 | 23 | |
| Pseudomonas aeruginosa (2) | 1 | 43 | 13 | |
| Enterobacter cloacae (1) | 2 | 65 | 6 | |
| Ofloxacin | Klebsiella oxytoca (1) | 0.3 | - | 17 |
| Moraxella catarrhalis (1) | 0,25 | - | 22 | |
| Enterobacter cloacae(2) | 0,25 | - | 46 | |
| Moraxella catarrhalis (2) | 0.3 | - | 36 | |
| Pseudomonas aeruginosa (3) | 2 | - | 5 | |
| Escherichia coli (3) | 1 | - | 6 | |
| Serratia sp. | 1 | - | 6 | |
| Piperacillin | Enterobacter cloacae (3) | 3 | 100 | 11 |
| Stenotrophomonas maltophila | 12.5 | 84 | 10 | |
| Streptococcus sp. (2) | 0,05 | 100 | 700 | |
| Escherichia coli (4) | 1 | 100 | 49 | |
| Acinetobacter baumanii (1) | 9 | 100 | 4 | |
| Enterobacter cloacae (4) | 3 | 100 | 11 | |
| Klebsiella oxytoca (2) | 14 | 100 | 9 | |
| Pseudomonas aeruginosa (4) | 2 | 100 | 20 | |
| Escherichia coli (5) | 26 | 58 | 5 | |
| Proteus mirabilis | 0,06 | 100 | 583 | |
| Acinetobacter baumanii (2) | 4 | 80 | 9 | |
| Escherichia coli (6) | 0.2 | 100 | 159 | |
| Streptococcus haemolysis | 0,05 | 65 | 10 | |
| Enterobacter aerogenes (1) | 1 | 100 | 49 | |
| Ceftriaxone | Escherichia coli (7) | 0,02 | 100 | 10000 |
| Enterococcus faecalis (4) | 6 | 48 | 35 | |
| Escherichia coli (8) | 0,02 | 83 | 10000 | |
| Enterococcus faecalis (5) | 0.3 | 58 | 588 | |
| Ertapenem | Klebsiella oxytoca (3) | 0,2 | 100 | 50 |
| Enterobacter cloacae (5) | 0,1 | 100 | 100 | |
| Escherichia coli (9) | 0.5 | 80 | 200 | |
| Enterobacter cloacae (6) | 1 | 90 | 100 | |
| Klebsiella oxytoca (4) | 0.5 | 90 | 200 | |
| Enterobacter cloacae (7) | 1 | 78 | 100 | |
| Klebsiella oxytoca (5) | 0,06 | 100 | 1667 | |
| Linezolid | Staphylococcus aureus (1) | 2.50 | 32 | 8 |
| Staphylococcus aureus (2) | 1 | 90 | 20 | |
| Staphylococcus aureus (3) | 0.5 | 80 | 40 | |
| Doripenem | Enterobacter cloacae (8) | 1 | 12 | |
| Enterobacter aerogenes (2) | 0,03 | 100 | 375 | |
| Acinetobacter baumanii (3) | 2 | 88 | 6 | |
| Pseudomonas aeruginosa (5) | 1 | 100 | 12 | |
| Pseudomonas aeruginosa (6) | 2 | 100 | 6 | |
| Pseudomonas aeruginosa (7) | 1 | 100 | 12 | |
| Enterococcus faecalis (6) | 1.5 | 80 | 9 | |
| Daptomycin | Staphylococcus aureus (4) | 0.5 | 100 | 110 |
| Staphylococcus aureus (5) | 1 | 90 | 55 | |
| Enterococcus faecalis (2) | 1 | 88 | 55 | |
| Enterococcus faecalis (3) | 1 | 70 | 55 | |
| Metronidazole | Bacterioides fragilis (1) | 0.5 | 90 | 20 |
| Bacterioides fragilis (2) | 0.5 | 90 | 20 |