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. 2019 Jul 16;62(16):7431–7444. doi: 10.1021/acs.jmedchem.9b00365

Table 2. Pharmacokinetic Profile of Compound 7f in Ratsa.

  po (25 mg/kg) iv (5 mg/kg)
AUC(0–∞) μg/(L h) 80 535.0 16 855.5
T1/2 (h) 1.7 0.9
Tmax (h) 4.0 0.083
Cmax (μg/L) 15 352.5 14 746.0
BA (%) 89.9  
a

SD rats (male, three animals per group) weighted 180–220 g were used for the study.