Table 2. Pharmacokinetic Profile of Compound 7f in Ratsa.
| po (25 mg/kg) | iv (5 mg/kg) | |
|---|---|---|
| AUC(0–∞) μg/(L h) | 80 535.0 | 16 855.5 |
| T1/2 (h) | 1.7 | 0.9 |
| Tmax (h) | 4.0 | 0.083 |
| Cmax (μg/L) | 15 352.5 | 14 746.0 |
| BA (%) | 89.9 |
SD rats (male, three animals per group) weighted 180–220 g were used for the study.