. 2019 Dec 17;63(2):756–783. doi: 10.1021/acs.jmedchem.9b01741

Table 1. Representative Hit from the T. b. brucei HTS¹⁸^,^a.

graphic file with name jm9b01741_0011.jpg

	targeted properties	1
T. b. brucei pEC₅₀	>7.5	8.2 ± 0.02
MRC5 pTC₅₀	<5	<4.3 ± 0.00
HepG2 pTC₅₀	<5	<4.0 ± 0.00
aq sol. (μM)	>10	<0.1
MW	≤360	310
cLogP	≤3	2.8
cLogD	≤2	3.6
MPO score	≥4	5.1
RH Cl_int*	≤9	66
HLM Cl_int**	≤5	210
PPB (%)	≤95	98

aq sol. = aqueous solubility. MW = molecular weight. MPO = multiparameter optimization. RH = rat hepatocyte. HLM = human liver microsome. PPB = plasma protein binding. ∗ = (μL/min)/10⁶ cells. ∗∗ = (μL/min)/mg protein.

Table 1. Representative Hit from the T. b. brucei HTS18,a.

Table 1. Representative Hit from the T. b. brucei HTS¹⁸^,^a.