. 2019 Dec 17;63(2):756–783. doi: 10.1021/acs.jmedchem.9b01741

Table 9. T. b. brucei Activity and ADME Properties for a Series of Combination Analogs, Combining Various R¹, R², and R³ Substituents^c.

graphic file with name jm9b01741_0025.jpg

Poor MS response.

No compound detected.

∗ = SEM within 0.13. ∗∗ = (μL/min)/10⁶ cells. ∗∗∗= (μL/min)/mg protein. nd = not determined. nt = not tested.

Table 9. T. b. brucei Activity and ADME Properties for a Series of Combination Analogs, Combining Various R1, R2, and R3 Substituentsc.