Table 2.

Mechanism of action of other therapeutic treatments used for trigeminal neuralgia.

Drug	Mechanisms of action	Therapeutic indication
Gabapentinoids	Cavα2δ subunit	Epilepsy, pain
Lamotrigine	VGSC blocker, N-P-type VGCC blocker	Epilepsy
Phenytoin	VGSC blocker	Epilepsy
Baclofen	GABAB receptor agonist	Spasticity
BoNT-A	SNARE complex	Spasticity

VGSC: voltage-gated sodium channel; VGCC: voltage-gated calcium channel; GABA: gamma-aminobutyric acid; BoNT-A: botulinum toxin type A; SNARE: SNAP receptor.