Table 1.
Associations between serum urate and epistatic interactions in PKD2 and ABCG2
| Chr. | SNP1 | Pos1 | A1 | SNP2 | Pos2 | A2 | Dist | LD (r2) | Estimate | Pint | Variance explained (%) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | rs2725215 | 88,961,571 | T | rs1481012 | 89,039,082 | G | 77,511 | 0.605 | Male | −2.309 | 0.693 | – |
| Female | −12.817 | 0.236 | – | |||||||||
| Total | −7.020 | 0.181 | – | |||||||||
| 4 | rs2725215 | 88,961,571 | T | rs2231137 | 89,061,114 | T | 99,543 | 0.116 | Male | 4.830 | 0.618 | – |
| Female | 20.178 | 0.220 | – | |||||||||
| Total | 9.306 | 0.270 | – | |||||||||
| 4 | rs2728121 | 88,997,102 | C | rs1481012 | 89,039,082 | G | 41,980 | 0.370 | Male | −6.051 | 0.379 | – |
| Female | −33.315 | 0.006 | 0.493 | |||||||||
| Total | −14.487 | 0.018 | 0.099 | |||||||||
| 4 | rs2728121 | 88,997,102 | C | rs2231137 | 89,061,114 | T | 64,012 | 0.045 | Male | 8.980 | 0.017 | 0.144 |
| Female | 9.250 | 0.171 | – | |||||||||
| Total | 9.781 | 0.004 | 0.164 |
Chr, chromosome of an SNP pair. SNP1 (SNP2), Pos1 (Pos2), name and position of the first (second) SNP. A1, effect allele of SNP1; A2, effect allele of SNP2. dist, distance in bp between two SNPs. LD (r2), linkage disequilibrium between two SNPs. Pint, P-value of the interaction between SNP pair in serum urate was calculated by linear regression adjusted age, gender, and target SNPs. Variance explained of the interaction between the SNP pair in serum urate was calculated by linear regression