. 2020 Jan 27;157:2. doi: 10.1186/s41065-020-0116-6

Table 2.

Associations between urate-related epistatic interactions and hyperuricemia/gout

SNP₁	SNP₂		Hyperuricemia Vs. Control			Gout Vs. Hyperuricemia			Gout Vs. Control
SNP₁	SNP₂		Estimate	SE	P_int	Estimate	SE	P_int	Estimate	SE	P_int
rs2728121	rs1481012	Male	−0.108	0.153	0.483	0.188	0.245	0.444	0.077	0.258	0.765
		Female	−0.648	0.272	0.017	−0.528	0.947	0.577	−0.897	0.835	0.282
		Total	−0.254	0.130	0.051	0.165	0.234	0.482	−0.004	0.239	0.987
rs2728121	rs2231137	Male	0.206	0.087	0.018	0.338	0.156	0.030	0.524	0.161	0.001
		Female	0.118	0.148	0.427	0.100	0.536	0.852	0.229	0.523	0.661
		Total	0.193	0.074	0.009	0.313	0.149	0.035	0.480	0.149	0.001

SNP₁ (SNP₂), name of the first (second) SNP. SE, standard error. P_int, P-value of the interaction between the SNP pair in hyperuricemia and gout were calculated by logistic regression adjusted age, gender, and target SNPs