. 2020 Jan 27;157:2. doi: 10.1186/s41065-020-0116-6

Table 3.

Associations between epistatic interactions and serum urate in subgroups of BMI and smoking status

SNP₁	SNP₂		Subgroup-1			Subgroup-2			Subgroup-3
SNP₁	SNP₂		Estimate	SE	P_int	Estimate	SE	P_int	Estimate	SE	P_int
rs2728121	rs1481012	BMI	19.794	41.811	0.637	−10.483	8.306	0.207	−21.702	9.477	0.022
rs2728121	rs1481012	Smoke	−25.467	15.210	0.095	−7.751	10.478	0.460	−9.196	8.343	0.271
rs2728121	rs2231137	BMI	24.512	22.948	0.288	11.456	4.620	0.013	9.844	4.962	0.047
rs2728121	rs2231137	Smoke	9.972	8.385	0.235	7.106	5.223	0.174	7.592	4.608	0.100

SNP₁ (SNP₂), name of the first (second) SNP. SE, standard error. P_int, P-value of the interaction between the SNP pair in serum urate was calculated by linear regression adjusted age, gender and target SNPs. Subgroup of BMI: 1, Underweight (BMI < 18.5); 2, Normal (18.5 ≦ BMI < 25); 3, Overweight (BMI ≧ 25). Subgroup of smoke: 1, non-smokers; 2, former smokers; 3, current smokers