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. 2020 Jan 27;18:14. doi: 10.1186/s12964-019-0496-2

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The bidirectional role of CSDE1 in translational reprogramming. (A) CSDE1 connects different protein regulators (A-F) with target RNAs to change the fate of RNAs. (B) The bidirectional role of CSDE1 in translational reprogramming. CSDE1 not only promotes and represses cap-dependent and cap-independent translation initiation of RNAs but also increases and decreases RNA abundance