TABLE 4.
Predicted antibiotic biosynthesis genes within Bacillus velezensis F85 genome.
| Synthetase | ||||
| type | Compound | Locus | Genes | Annotation |
| NRPS | Lipopeptides | gene4273 | ppsA | Fengycin family lipopeptide synthetase A |
| gene4274 | ppsB | Fengycin family lipopeptide synthetase B | ||
| gene4275 | ppsC | Fengycin family lipopeptide synthetase C | ||
| gene0001 | ppsD | Fengycin family lipopeptide synthetase D | ||
| gene0002 | ppsE | Fengycin family lipopeptide synthetase E | ||
| gene0029 | ituA | Iturin family lipopeptide synthetase A | ||
| gene0030 | ituB | Iturin family lipopeptide synthetase B | ||
| gene0031 | ituC | Iturin family lipopeptide synthetase C | ||
| gene1993 | srfAB | Surfactin family lipopeptide synthetase B | ||
| gene1994 | srfAC | Surfactin family lipopeptide synthetase C | ||
| gene4276 | srfAA | Surfactin family lipopeptide synthetase A | ||
| Peptide | gene1416 | bacA | bacA; prephenate decarboxylase | |
| gene1417 | bacB | 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase | ||
| gene1418 | bacC | Dihydroanticapsin dehydrogenase | ||
| gene1419 | bacD | L-Alanine-L-anticapsin ligase | ||
| gene1420 | bacE | MFS transporter, DHA3 family, bacilysin exporter BacE | ||
| gene1421 | bacF | Bacilysin biosynthesis transaminase BacF | ||
| gene1422 | bacG | Bacilysin biosynthesis oxidoreductase BacG | ||
| Polyketide | gene0153 | pksS | Cytochrome P450 PksS | |
| gene0154 | pksR | Polyketide synthase PksR | ||
| gene0155 | pksN | Polyketide synthase PksN | ||
| gene0156 | pksM | Polyketide synthase PksM | ||
| gene0157 | pksL | Polyketide synthase PksL | ||
| gene0158 | pksJ | Polyketide synthase PksJ | ||
| gene0159 | pksI | Polyketide biosynthesis enoyl-CoA hydratase PksI | ||
| gene0160 | pksH | Polyketide biosynthesis enoyl-CoA hydratase PksH | ||
| gene0161 | pksG | Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-CoA synthase-like enzyme PksG | ||
| gene0162 | acpK | Polyketide biosynthesis acyl carrier protein | ||
| gene0163 | pksE | Trans-AT polyketide synthase, acyltransferase and oxidoreductase domains | ||
| gene0164 | pksD | Bacillaene synthase trans-acting acyltransferase | ||
| gene0165 | pksC | Polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase | ||
| Terpenoid | gene0219 | dxr | 1-Deoxy-D-xylulose-5-phosphate reductoisomerase | |
| gene0221 | uppS | Undecaprenyl diphosphate synthase | ||
| gene0886 | atoB | Acetyl-CoA C-acetyltransferase | ||
| gene2645 | ispH | 4-Hydroxy-3-methylbut-2-en-1-yl diphosphate reductase | ||
| gene2655 | gcpE | (E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase | ||
| gene2736 | dxs | 1-Deoxy-D-xylulose-5-phosphate synthase | ||
| gene2752 | atoB | Acetyl-CoA C-acetyltransferase | ||
| gene2899 | idi | Isopentenyl-diphosphate delta-isomerase | ||
| gene2911 | hepST | Heptaprenyl diphosphate synthase | ||
| gene2913 | hepST | Heptaprenyl diphosphate synthase | ||
| gene4160 | ispF | 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase | ||
| gene4161 | ispD | 2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase | ||
| gene4209 | ispE | 4-Diphosphocytidyl-2-C-methyl-D-erythritol kinase | ||
| RPS | Bacteriocin | gene1826 | nisF | Lantibiotic transport system ATP-binding protein |
| gene1827 | nisE | Lantibiotic transport system permease protein | ||
| gene1828 | nisG | Lantibiotic transport system permease protein | ||
| gene1829 | nisR | Two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR | ||
| Antibacterial proteins | gene2701 | tasA | Spore coat-associated protein N |