FIGURE 1.
Selected results of survival analysis of time to viral suppression (A, B) and time to AIDS after HAART (C, D). Number of patients and number of events (N), P value (P), and RH are based on Cox proportional hazards models. A, Kaplan-Meier plot of time to < 200 HIV RNA copies/mL for the CCR5-Δ32 dominant model. B, Viral suppression to < 50 HIV RNA copies/mL for the CX3CR1-V249I codominant model. C, D, Time to AIDS after HAART initiation for the CCR5-Δ 32 dominant and SDF1–3′ UTR recessive models, respectively. All hazard ratios were adjusted for baseline viral load and baseline CD4 lymphocyte count. Cox proportional hazards models for time to viral suppression were also adjusted for the occurrence of clinical AIDS before HAART initiation. Those patients with their first clinical AIDS before HAART initiation were excluded from analyses of AIDS progression. Age at HAART initiation was included as a covariate in Cox proportional hazards for AIDS progression.