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Schematic presentation of the proposed mechanistic pathways mediating the effects of obesity on development of uterine leiomyomas. ↑ and ↓ denote increased or decreased level or function, respectively. + and − denote enhancing or suppressing effect, respectively. IGF1, insulin-like growth factor I; IGFBP, IGF-binding protein; IL, interleukin; TNF, tumor necrosis factor.
