Chromatograms of a serum sample with 2.2 nM of progesterone (a,b) and 0.3 nM of 11-deoxycorticosterone (c,d) with DMS off in the top panels (a,c) and DMS on in the bottom panels (b,d). DMS demonstrated an increase in the signal-to-noise ratio by reducing the noise through mobility selection. Reproduced with permission from Ray et al. [11], copyright 2014 Elsevier B. V.