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Schematic showing the composition of complexes involved in chromosome end protection and end replication. The shelterin complex (POT1, TPP1, TRF1, TRF2, TIN2, and Rap1 proteins) protects chromosome ends from ATM kinase and ATR kinase-mediated DNA damage response pathways. The telomerase RNP (TERT protein and TR RNA subunits) adds telomeric DNA de novo at the 3′ ends of chromosomes
