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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: Adv Exp Med Biol. 2019;1197:11–26. doi: 10.1007/978-3-030-28524-1_2

Figure 1: Immuno-epigeno-metabolic crosstalk in trained innate immunity.

Figure 1:

Outline of major mechanisms by which innate immune signaling-triggered metabolic pathways induce epigenetic changes and how these prime for heightened secondary immune responses or trained immunity, which also cross-talks with metabolism. See text for details.