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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: Cancer Res. 2014 Dec 8;75(2):367–377. doi: 10.1158/0008-5472.CAN-14-2304

Figure 5.

Figure 5.

Effect of LOX activity inhibition on thyroid cancer biology in vitro and in vivo. A, inhibition of LOX activity does not affect cellular proliferation. BAPN (100, 250, and 500 μmol/L) was used with a CyQUANT assay to evaluate the effect of LOX inhibition on cellular proliferation. B, LOX activity inhibition reduces cellular migration and invasion in ATC cell lines. Transwell migration and invasion assays were performed after 24 hours of treatment with and without 100 μmol/L of BAPN. C, LOX inhibition reduces only vimentin expression in ATC cells. The cell lines were treated with and without 100 μmol/L of BAPN over 48 hours. RFU, relative fluorescence units.